Publications at the Department of Mathematics and Natural Sciences from 2019

Results: 927
Created on: Tue, 16 Jul 2024 23:09:44 +0200 in 0.0805 sec


Grebinyk, Anna; Prylutska, Svitlana; Grebinyk, Sergii; Prylutskyy, Yuriy; Ritter, Uwe; Matyshevska, Olga; Dandekar, Thomas; Frohme, Marcus
Toward photodynamic cancer chemotherapy with C60-Doxorubicin nanocomplexes. - In: Nanomaterials for photodynamics therapy, (2023), S. 489-522

Recent progress in nanotechnology has attracted interest to a biomedical application of the carbon nanoparticle C60 fullerene (C60) due to its unique structure and versatile biological activity. The dual functionality of C60 as a photosensitizer and a drug nanocarrier sets an opportunity to improve the efficiency of chemotherapeutic drugs for cancer cells. Pristine C60 demonstrates time-dependent accumulation with predominant mitochondrial localization in cancer cells. Nanomolar amounts of C60-drug nanocomplexes in 1:1 and 2:1 molar ratios improve the efficiency of cell treatment, complementing it with photodynamic approach. The cooperative enhancement interactions between mechanisms of chemo- and photodynamic therapies contribute to the obtained synergistic effect (namely “1+1>2”). A strong synergy of treatments arising from the combination of C60-mediated drug delivery and C60 photoexcitation indicates that a combination of chemo- and photodynamic treatments with C60-drug nanoformulations could provide a promising synergetic approach for cancer treatment.



https://doi.org/10.1016/B978-0-323-85595-2.00005-0
Lüdge, Kathy;
Photonic reservoir computing for energy efficient and versatile machine learning application. - In: Proceedings of the Royal Society of Victoria, Bd. 135 (2023), 2, S. 38-40

Time-multiplexed reservoir computing is a machine learning concept which can be realised in photonic hardware systems using only one physical node. The concept can be used for various problems, ranging from classification problems to time-series prediction tasks, while being fast and energy efficient. Here, a theoretical analysis of a reservoir computer realised via delay-coupled semiconductor lasers is presented and the role of the internal system time-scales and the bifurcation structure is discussed. It is further shown that optimal performance can be reached by tailoring the coupling delays to the specific memory requirements of the given task.



https://doi.org/10.1071/rs23006
Jaster, Jonas; Dreßler, Elias; Geitner, Robert; Groß, Gregor Alexander
Synthesis and spectroscopic characterization of furan-2-carbaldehyde-d. - In: Molbank, ISSN 1422-8599, Bd. 2023 (2023), 2, M1654, S. 1-9

Here, we present a protocol for the one-step synthesis of the title compound in quantitative yield using adapted Vilsmeier conditions. The product was characterized by 1H-,2H-,13C-NMR-, as well as IR and Raman spectroscopy. Spectral data are given in detail.



https://doi.org/10.3390/M1654
Eckstein, Daniel; Schumann, Berit; Glahn, Felix; Krings, Oliver; Schober, Andreas; Foth, Heidi
Comparison of a 3D co-culture and a mini organ culture by testing barium sulphate and titanium dioxide nanoparticle aerosols. - In: Naunyn-Schmiedeberg's archives of pharmacology, ISSN 1432-1912, Bd. 396 (2023), 1, P055, S. S37

https://doi.org/10.1007/s00210-023-02397-6
Goor, Pieter; vanMahony, Robert; Schaller, Manuel; Worthmann, Karl
Reprojection methods for Koopman-based modelling and prediction. - In: CDC 2023 Singapore, (2023), S. 315-321

Extended Dynamic Mode Decomposition (eDMD) is a powerful tool to generate data-driven surrogate models for the prediction and control of nonlinear dynamical systems in the Koopman framework. In eDMD a compression of the lifted system dynamics on the space spanned by finitely many observables is computed, in which the original space is embedded as a low-dimensional manifold. While this manifold is invariant for the infinite-dimensional Koopman operator, this invariance is typically not preserved for its eDMD-based approximation. Hence, an additional (re-)projection step is often tacitly incorporated to improve the prediction capability. We propose a novel framework for consistent reprojectors respecting the underlying manifold structure. Further, we present a new geometric reprojector based on maximum-likelihood arguments, which significantly enhances the approximation accuracy and preserves known finite-data error bounds.



https://doi.org/10.1109/CDC49753.2023.10383796
Yeo, Yi Lin; Kirlangic, Mehmet Eylem; Heyder, Stefan; Supriyanto, Eko; Mohamad Salim, Maheza I.; Fiedler, Patrique; Haueisen, Jens
Linear versus quadratic detrending in analyzing simultaneous changes in DC-EEG and transcutaneous pCO2. - In: 2023 45th Annual International Conference of the IEEE Engineering in Medicine & Biology Conference (EMBC), (2023), insges. 4 S.

Physiological direct current (DC) potential shifts in electroencephalography (EEG) can be masked by artifacts such as slow electrode drifts. To reduce the influence of these artifacts, linear detrending has been proposed as a pre-processing step. We considered quadratic detrending, which has hardly been addressed for ultralow frequency components in EEG. We compared the performance of linear and quadratic detrending in simultaneously acquired DC-EEG and transcutaneous partial pressure of carbon dioxide during two activation methods: hyperventilation (HV) and apnea (AP). Quadratic detrending performed significantly better than linear detrending in HV, while for AP, our analysis was inconclusive with no statistical significance. We conclude that quadratic detrending should be considered for DC-EEG preprocessing.



https://doi.org/10.1109/EMBC40787.2023.10340855
Berger, Thomas; Lanza, Lukas
Funnel control of linear systems with arbitrary relative degree under output measurement losses. - In: IMA journal of mathematical control and information, ISSN 1471-6887, Bd. 40 (2023), 4, S. 691-713

We consider tracking control of linear minimum phase systems with known arbitrary relative degree which are subject to possible output measurement losses. We provide a control law which guarantees the evolution of the tracking error within a (shifted) prescribed performance funnel whenever the output signal is available. The result requires a maximal duration of measurement losses and a minimal time of measurement availability, which both strongly depend on the internal dynamics of the system, and are derived explicitly. The controller is illustrated by a simulation of a mass-on-car system.



https://doi.org/10.1093/imamci/dnad029
Schmitz, Philipp; Lanza, Lukas; Worthmann, Karl
Safe data-driven reference tracking with prescribed performance. - In: 2023 27th International Conference on System Theory, Control and Computing (ICSTCC), (2023), S. 454-460
ISBN 979-8-3503-3798-3

We study output reference tracking for unknown continuous-time systems with arbitrary relative degree. The control objective is to keep the tracking error within predefined time-varying bounds while measurement data is only available at discrete sampling times. To achieve the control objective, we propose a two-component controller. One part is a recently developed sampled-data zero-order hold controller, which achieves reference tracking within prescribed error bounds. To further improve the control signal, we explore the system dynamics via input-output data, and include as the second component a data-driven MPC scheme based on Willems et al.’s fundamental lemma. This combination yields significantly improved input signals as illustrated by a numerical example.



https://doi.org/10.1109/ICSTCC59206.2023.10308521
Mühlnickel, Lukas; Jaurigue, Lina; Lüdge, Kathy
Delay-based reservoir computing with spin-VCSELs: interplay between internal dynamics and performance. - In: 2023 Conference on Lasers and Electro-Optics Europe & European Quantum Electronics Conference (CLEO/Europe-EQEC), (2023), insges. 1 S.

Machine learning setups that are able to process data in the optical domain are ideal for on -chip hardware implementations [1]. Due to the fact that the training of hardware based solutions is complicated, a delay-based reservoir computing (RC) realization, where only the output weights need to be trained via linear regression, is very promising [2]. In this paper we investigate vertical cavity surface emitting laser with two mode emission (spin-VCSEL) as the nonlinear node for a delay-based RC setup. These lasers have the ability to exibit reprodicible and high speed dynamics [3] and are thus ideal candidates to increase the data injection rates which are limited by the clocktime [4], [5]. The focus of our numerical investigations is on the interplay between the internal charge carrier dynamics of the spin-VCSEL and its performance when operated in a delay-based RC setup with optically-injected phase-modulated data injection.



https://doi.org/10.1109/CLEO/Europe-EQEC57999.2023.10232555
Bohm, Sebastian; Grunert, Malte; Schwarz, Felix; Runge, Erich; Wang, Dong; Schaaf, Peter; Chimeh, Abbas; Lienau, Christoph
Gold nanosponges: fascinating optical properties of a unique disorder-dominated system. - In: Journal of the Optical Society of America, ISSN 1520-8540, Bd. 40 (2023), 6, S. 1491-1509

Nanoporous gold is a three-dimensional bulk material that is percolated with a random network of nanometer-sized ligaments and made by selective corrosion of bimetallic alloys. It has intriguing geometric, catalytic, and optical properties that have fascinated scientists for many decades. When such a material is made into the form of small, 100-nm-sized particles, so-called nanosponges emerge that offer much flexibility in controlling their geometric, electronic, and optical properties. Importantly, these particles act as an antenna for light that can efficiently localize optical fields on a deep subwavelength scale in certain hotspots at the particle surface. This makes such nanosponges an interesting platform for plasmonic sensing, photocatalysis, and surface-enhanced Raman spectroscopy. Since the optical properties of these nanosponges can be controlled to a large degree by tuning their geometry and/or composition, they have attracted increasing attention in recent years. Here, we provide a concise overview of the current state of the art in this field, covering their fabrication, computational modeling, and specifically the linear and nonlinear optical properties of individual and hybrid nanosponges, for example, plasmon localization in randomly disordered hotspots with a size <10 nm and a long lifetime with an exceptionally high Purcell factor. The resulting nonlinear optical and photoemission properties are discussed for individual and hybrid nanosponges. The results presented have strong implications for further applications of such nanosponges in photonics and photocatalysis.



https://doi.org/10.1364/JOSAB.479739