Magnetite-arginine nanoparticles as a multifunctional biomedical tool. - In: Nanomaterials, ISSN 2079-4991, Bd. 10 (2020), 10, 2014, insges. 14 S.
Iron oxide nanoparticles are a promising platform for biomedical applications, both in terms of diagnostics and therapeutics. In addition, arginine-rich polypeptides are known to penetrate across cell membranes. Here, we thus introduce a system based on magnetite nanoparticles and the polypeptide poly-l-arginine (polyR-Fe3O4). We show that the hybrid nanoparticles exhibit a low cytotoxicity that is comparable to Resovist®, a commercially available drug. PolyR-Fe3O4 particles perform very well in diagnostic applications, such as magnetic particle imaging (1.7 and 1.35 higher signal respectively for the 3rd and 11th harmonic when compared to Resovist®), or as contrast agents for magnetic resonance imaging (R2/R1 ratio of 17 as compared to 11 at 0.94 T for Resovist®). Moreover, these novel particles can also be used for therapeutic purposes such as hyperthermia, achieving a specific heating power ratio of 208 W/g as compared to 83 W/g for Feridex®, another commercially available product. Therefore, we envision such materials to play a role in the future theranostic applications, where the arginine ability to deliver cargo into the cell can be coupled to the magnetite imaging properties and cancer fighting activity.
https://doi.org/10.3390/nano10102014
From simulation to reality: a implementable self-organized collision avoidance algorithm for autonomous UAVs. - In: 2020 International Conference on Unmanned Aircraft Systems, (2020), S. 822-831
https://doi.org/10.1109/ICUAS48674.2020.9213998
Improving network-assisted roaming for controller-less Wi-Fi. - In: 2020 IEEE 31st Annual International Symposium on Personal, Indoor and Mobile Radio Communications, (2020), insges. 7 S.
https://doi.org/10.1109/PIMRC48278.2020.9217269
Cutting through the jungle: disambiguating model-based traceability terminology. - In: 28th IEEE International Requirements Engineering Conference, (2020), S. 8-19
https://doi.org/10.1109/RE48521.2020.00014
Autonomous mobile gait training robot for orthopedic rehabilitation in a clinical environment. - In: Robots with heart, mind, and soul, (2020), S. 580-587
https://doi.org/10.1109/RO-MAN47096.2020.9223482
Socially compliant human-robot interaction for autonomous scanning tasks in supermarket environments. - In: Robots with heart, mind, and soul, (2020), S. 363-370
https://doi.org/10.1109/RO-MAN47096.2020.9223568
A laser projection system for robot intention communication and human robot interaction. - In: Robots with heart, mind, and soul, (2020), S. 259-265
https://doi.org/10.1109/RO-MAN47096.2020.9223517
Datenbanken : Kompaktkurs
1. Auflage. - Frechen : mitp, 2020. - 1 Online-Ressource (352 Seiten). - (mitp Professional) ISBN 978-3-95845-783-6
Cover -- Inhaltsverzeichnis -- Vorwort -- Was sind Datenbanken? -- Warum Datenbanken? -- Datenbanksysteme -- Anforderungen: Die Codd'schen Regeln -- DBMS-Architektur -- Datenunabhängigkeit -- Transaktionen -- Konkrete Datenbankmanagementsysteme -- Einsatzgebiete und Grenzen -- Beispielanwendungen -- Übersicht über die Kapitel des Buches -- Übungsaufgaben -- Relationale Datenbanken - Daten als Tabellen -- Relationen für tabellarische Daten -- Integritätsbedingungen: Schlüssel und Fremdschlüssel -- Tabellendefinition in SQL -- Anfrageoperationen auf Tabellen -- Selektion -- Projektion -- Natürlicher Verbund -3mu -- Umbenennung -- Mengenoperationen , , - -- Anfragen in SQL -- Änderungsoperationen in SQL -- Zusammenfassung -- Übungsaufgaben -- Das Entity-Relationship- Modell -- Eigenschaften von Datenbankmodellen -- Einführung in das Entity-Relationship-Modell -- Grundkonzepte -- Ein einfaches Beispiel für ein ER-Schema -- ER-Modellierungskonzepte -- Wert und Attribut -- Entity und Entity-Typ -- Beziehung und Beziehungstyp -- Identifizierung durch Schlüssel -- Kardinalitäten -- n:m-Beziehung -- 1:n-Beziehung -- 1:1-Beziehung -- Optionale und zwingende Beziehungen -- Abhängige Entity-Typen -- Die Ist-Beziehung -- Alternative Notationen für Kardinalitäten -- Zusammenfassung -- Übungsaufgaben -- Datenbankentwurf -- Der Datenbankentwurfsprozess -- Ziele des Datenbankentwurfs -- Das Phasenmodell -- Formalisierung des Relationenmodells -- Logischer Datenbankentwurf: Abbildung auf Relationen -- Übersicht über die Abbildungsregeln -- Abbildung von Entity-Typen -- Abbildung von Beziehungstypen -- Abbildung eines abhängigen Entity-Typs -- Abbildung der Ist-Beziehung -- Komplexere Beispiele -- Zusammenfassung -- Übungsaufgaben -- Normalisierung für eine redundanzfreie Datenbank -- Funktionale Abhängigkeiten -- Schema-Eigenschaften -- Update-Anomalien.
https://ebookcentral.proquest.com/lib/kxp/detail.action?docID=6363308
A KPI-based soft sensor development approach incorporating infrequent, variable time delayed measurements. - In: IEEE transactions on control systems technology, ISSN 1558-0865, Bd. 28 (2020), 6, S. 2523-2531
The overall performance of complex industrial systems using control and optimization strategies is often hampered by the lack of available measurements of key quality variables. The development of a soft sensor is a solution that allows for the necessary process information to be made available. Due to the nonlinear characteristics of industrial processes, a new soft sensor development approach that incorporates infrequent, variable time delayed measurements is proposed. Based on the fast-sampled measurement and the nonlinear, first principles model, the frequent and delay-free key performance indicator (KPI) estimation is realized using the square-root unscented Kalman filter (SR-UKF). Then, a modified Kalman Filter (MKF) algorithm is proposed to deal with those infrequent, but accurate measurements, whose values are variably delayed in time. These two types of estimates are fused and optimized to give an optimal, reliable KPI estimate based on the distributed state fusion UKF filter algorithm. The performance and effectiveness of the proposed approach are demonstrated by an experimental application for alumina concentration monitoring in the aluminum electrolysis industry.
https://doi.org/10.1109/TCST.2019.2929478
Synthesis and characterization of citrate-stabilized gold-coated superparamagnetic iron oxide nanoparticles for biomedical applications. - In: Molecules, ISSN 1420-3049, Bd. 25 (2020), 19, 4425, insges. 23 S.
Surface-functionalized gold-coated superparamagnetic iron oxide nanoparticles (Au-SPIONs) may be a useful tool in various biomedical applications. To obtain Au-SPIONs, gold salt was precipitated onto citrate-stabilized SPIONs (Cit-SPIONs) using a simple, aqueous one-pot technique inspired by the Turkevich method of gold nanoparticle synthesis. By the further stabilization of the Au-SPION surface with additional citrate (Cit-Au-SPIONs), controllable and reproducible Z-averages enhanced long-term dispersion stability and moderate dispersion pH values were achieved. The citrate concentration of the reaction solution and the gold/iron ratio was found to have a major influence on the particle characteristics. While the gold-coating reduced the saturation magnetization to 40.7% in comparison to pure Cit-SPIONs, the superparamagnetic behavior of Cit-Au-SPIONs was maintained. The formation of nanosized gold on the SPION surface was confirmed by X-ray diffraction measurements. Cit-Au-SPION concentrations of up to 100 [my]g Fe/mL for 48 h had no cytotoxic effect on Jurkat cells. At a particle concentration of 100 [my]g Fe/mL, Jurkat cells were found to take up Cit-Au-SPIONs after 24 h of incubation. A significantly higher attachment of thiol-containing L-cysteine to the particle surface was observed for Cit-Au-SPIONs (53%) in comparison to pure Cit-SPIONs (7%).
https://doi.org/10.3390/molecules25194425