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Weise, Konstantin; Wartman, William A.; Knösche, Thomas R.; Nummenmaa, Aapo R.; Makarov, Sergey N.
The effect of meninges on the electric fields in TES and TMS. Numerical modeling with adaptive mesh refinement. - In: Brain stimulation, ISSN 1876-4754, Bd. 15 (2022), 3, S. 654-663

Background - When modeling transcranial electrical stimulation (TES) and transcranial magnetic stimulation (TMS) in the brain, the meninges - dura, arachnoid, and pia mater - are often neglected due to high computational costs. - Objective - We investigate the impact of the meningeal layers on the cortical electric field in TES and TMS while considering the headreco segmentation as the base model. - Method - We use T1/T2 MRI data from 16 subjects and apply the boundary element fast multipole method with adaptive mesh refinement, which enables us to accurately solve this problem and establish method convergence at reasonable computational cost. We compare electric fields in the presence and absence of various meninges for two brain areas (M1HAND and DLPFC) and for several distinct TES and TMS setups. - Results - Maximum electric fields in the cortex for focal TES consistently increase by approximately 30% on average when the meninges are present in the CSF volume. Their effect on the maximum field can be emulated by reducing the CSF conductivity from 1.65 S/m to approximately 0.85 S/m. In stark contrast to that, the TMS electric fields in the cortex are only weakly affected by the meningeal layers and slightly (∼6%) decrease on average when the meninges are included. - Conclusion - Our results quantify the influence of the meninges on the cortical TES and TMS electric fields. Both focal TES and TMS results are very consistent. The focal TES results are also in a good agreement with a prior relevant study. The solver and the mesh generator for the meningeal layers (compatible with SimNIBS) are available online.



https://doi.org/10.1016/j.brs.2022.04.009
Weise, Konstantin; Müller, Erik; Poßner, Lucas; Knösche, Thomas R.
Comparison of the performance and reliability between improved sampling strategies for polynomial chaos expansion. - In: Mathematical biosciences and engineering, ISSN 1551-0018, Bd. 19 (2022), 8, S. 7425-7480

As uncertainty and sensitivity analysis of complex models grows ever more important, the difficulty of their timely realizations highlights a need for more efficient numerical operations. Non-intrusive Polynomial Chaos methods are highly efficient and accurate methods of mapping input-output relationships to investigate complex models. There is substantial potential to increase the efficacy of the method regarding the selected sampling scheme. We examine state-of-the-art sampling schemes categorized in space-filling-optimal designs such as Latin Hypercube sampling and L1-optimal sampling and compare their empirical performance against standard random sampling. The analysis was performed in the context of L1 minimization using the least-angle regression algorithm to fit the GPCE regression models. Due to the random nature of the sampling schemes, we compared different sampling approaches using statistical stability measures and evaluated the success rates to construct a surrogate model with relative errors of < 0.1 %, < 1 %, and < 10 %, respectively. The sampling schemes are thoroughly investigated by evaluating the y of surrogate models constructed for various distinct test cases, which represent different problem classes covering low, medium and high dimensional problems. Finally, the sampling schemes are tested on an application example to estimate the sensitivity of the self-impedance of a probe that is used to measure the impedance of biological tissues at different frequencies. We observed strong differences in the convergence properties of the methods between the analyzed test functions.



https://doi.org/10.3934/mbe.2022351
Feldhoff, Frank; Töpfer, Hannes; Harczos, Tamas; Klefenz, Frank
Periodicity pitch perception part III: sensibility and Pachinko volatility. - In: Frontiers in neuroscience, ISSN 1662-453X, Bd. 16 (2022), 736642, S. 1-15

Neuromorphic computer models are used to explain sensory perceptions. Auditory models generate cochleagrams, which resemble the spike distributions in the auditory nerve. Neuron ensembles along the auditory pathway transform sensory inputs step by step and at the end pitch is represented in auditory categorical spaces. In two previous articles in the series on periodicity pitch perception an extended auditory model had been successfully used for explaining periodicity pitch proved for various musical instrument generated tones and sung vowels. In this third part in the series the focus is on octopus cells as they are central sensitivity elements in auditory cognition processes. A powerful numerical model had been devised, in which auditory nerve fibers (ANFs) spike events are the inputs, triggering the impulse responses of the octopus cells. Efficient algorithms are developed and demonstrated to explain the behavior of octopus cells with a focus on a simple event-based hardware implementation of a layer of octopus neurons. The main finding is, that an octopus’ cell model in a local receptive field fine-tunes to a specific trajectory by a spike-timing-dependent plasticity (STDP) learning rule with synaptic pre-activation and the dendritic back-propagating signal as post condition. Successful learning explains away the teacher and there is thus no need for a temporally precise control of plasticity that distinguishes between learning and retrieval phases. Pitch learning is cascaded: At first octopus cells respond individually by self-adjustment to specific trajectories in their local receptive fields, then unions of octopus cells are collectively learned for pitch discrimination. Pitch estimation by inter-spike intervals is shown exemplary using two input scenarios: a simple sinus tone and a sung vowel. The model evaluation indicates an improvement in pitch estimation on a fixed time-scale.



https://doi.org/10.3389/fnins.2022.736642
Dürr, André; Böhm, Dennis; Schwarz, Dominik; Häfner, Stephan; Thomä, Reiner; Waldschmidt, Christian
Coherent measurements of a multistatic MIMO radar network with phase noise optimized non-coherent signal synthesis. - In: IEEE journal of microwaves, ISSN 2692-8388, Bd. 2 (2022), 2, S. 239-252

For multistatic radar networks in the upper mm-wave range with a large spacing between its radar sensor nodes, a coherent signal distribution is very complex and thus very costly. Hence, it is desirable to generate the mm-wave signals individually for each radar sensor node, i.e., non-coherently. However, multistatic radar networks using a non-coherent signal distribution for its radar sensor nodes are affected by systematic errors and uncorrelated phase noise, which reduces the resolution and the detection performance of these systems. In this article, a novel non-coherent signal synthesis concept based on the direct digital synthesis (DDS) principle is presented for multistatic radar networks. Compared to a signal synthesis using a phase-locked loop (PLL), it is shown that the different phase noise behavior of the DDS is beneficial for bistatic signal paths between the radar sensor nodes. The presented hardware concept is considered and analyzed for three different types of coherency regarding the signal distribution: coherent, quasi-coherent, and incoherent. Measurements with a multiple-input multiple-output (MIMO) radar at 150GHz prove that despite 150 GHz prove that despite a non-coherent signal distribution, it is possible to achieve the same detection and imaging performance as with a fully coherent radar by using a DDS.



https://doi.org/10.1109/JMW.2022.3154886
Reum, Thomas; Töpfer, Hannes
Investigation of electromagnetic wave propagation in the bicomplex 3D-FEM using a wavenumber Whitney Hodge operator. - In: Compel, ISSN 2054-5606, Bd. 41 (2022), 3, S. 996-1010

Purpose - The purpose of this paper is to show the applicability of a discrete Hodge operator in the context of the De Rham cohomology to bicomplex-valued electromagnetic wave propagation problems. It was applied in the finite element method (FEM) to get a higher accuracy through conformal discretization. Therewith, merely the primal mesh is needed to discretize the full system of Maxwell equations. Design/methodology/approach - At the beginning, the theoretical background is presented. The bicomplex number system is used as a geometrical algebra to describe three-dimensional electromagnetic problems. Because we treat rotational field problems, Whitney edge elements are chosen in the FEM to realize a conformal discretization. Next, numerical simulations regarding practical wave propagation problems are performed and compared with the common FEM approach using the Helmholtz equation. Findings - Different field problems of three-dimensional electromagnetic wave propagation are treated to present the merits and shortcomings of the method, which calculates the electric and magnetic field at the same spatial location on a primal mesh. A significant improvement in accuracy is achieved, whereas fewer essential boundary conditions are necessary. Furthermore, no numerical dispersion is observed. Originality/value - A novel Hodge operator, which acts on bicomplex-valued cotangential spaces, is constructed and discretized as an edge-based finite element matrix. The interpretation of the proposed geometrical algebra in the language of the De Rham cohomology leads to a more comprehensive viewpoint than the classical treatment in FEM. The presented paper may motivate researchers to interpret the form of number system as a degree of freedom when modeling physical effects. Several relationships between physical quantities might be inherently implemented in such an algebra.



https://doi.org/10.1108/COMPEL-03-2021-0078
Wagner, Christoph; Semper, Sebastian; Kirchhof, Jan
fastmat: efficient linear transforms in Python. - In: SoftwareX, ISSN 2352-7110, Bd. 18 (2022), 101013, S. 1-8

Scientific computing requires handling large linear models, which are often composed of structured matrices. With increasing model size, dense representations quickly become infeasible to compute or store. Matrix-free implementations are suited to mitigate this problem at the expense of additional implementation overhead, which complicates research and development effort by months, when applied to practical research problems. Fastmat is a framework for handling large structured matrices by offering an easy-to-use abstraction model. It allows for the expression of matrix-free linear operators in a mathematically intuitive way, while retaining their benefits in computation performance and memory efficiency. A built-in hierarchical unit-test system boosts debugging productivity and run-time execution path optimization improves the performance of highly-structured operators. The architecture is completed with an interface for abstractly describing algorithms that apply such matrix-free linear operators, while maintaining clear separation of their respective implementation levels. Fastmat achieves establishing a close relationship between implementation code and the actual mathematical notation of a given problem, promoting readable, portable and re-usable scientific code.



https://doi.org/10.1016/j.softx.2022.101013
Solomitckii, Dmitrii; Heino, Mikko; Buddappagari, Sreehari; Hein, Matthias; Valkama, Mikko
Radar scheme with raised reflector for NLOS vehicle detection. - In: IEEE transactions on intelligent transportation systems, Bd. 23 (2022), 7, S. 9037-9045

The employment of passive reflectors enables the millimeter-wave automotive radars to detect an approaching vehicle in non-line-of-sight conditions. In this paper, the installation of such reflectors above the sidewalk at an intersection is proposed and studied, avoiding pedestrians' blockage and road dust effect at ground level. Through the analysis of the backscattering power, it is shown that the suggested scheme may detect an approaching vehicle in the blind zone at distances of 30,łdots,50 m to the intersection point. Additionally, the analysis shows that efficient operation is highly dependent on the spatial orientation and size of the reflector. Even a few degrees rotation may change the detecting range by several meters. In turn, the larger area of the reflector may cover longer detecting distances, improving the radar scheme's overall performance. It is also shown that further performance enhancement can be achieved by employing a C-type radar, contributing an extra 5 dB to the backscattering power relative to an A-type radar. However, despite these improvements, the strongest scattering centre of the detectable vehicle is systematically identified to the bumper zone.



https://doi.org/10.1109/TITS.2021.3090313
Gholamhosseinian, Ashkan; Seitz, Jochen
A comprehensive survey on cooperative intersection management for heterogeneous connected vehicles. - In: IEEE access, ISSN 2169-3536, Bd. 10 (2022), S. 7937-7972

https://doi.org/10.1109/ACCESS.2022.3142450
Almeida, André L. F. de; Antreich, Felix; Haardt, Martin; Cavalcante, Charles C.
Kronecker product-based space-time block codes. - In: IEEE wireless communications letters, ISSN 2162-2345, Bd. 11 (2022), 2, S. 386-390

This letter presents a new approach to construct space-time block codes (STBCs) based on the Kronecker product. The proposed Kronecker-structured STBCs (K-STBCs) are specially designed for constant modulus constellations and include the classical linear dispersion (LD) codes as a special case. Its inherent Kronecker structure offers additional coding gains due to the mutual spreading of multiple space-time codewords. At the receiver, an efficient algorithm is derived by recasting the decoding of the K-STBCs as a rank-one tensor approximation problem. The proposed decoding algorithm provides a good bit error ratio (BER) performance especially, in the low signal-to-noise ratio (SNR) regime. In particular, our numerical results show that K-STBCs outperform the existing quasi-orthogonal STBCs due to the denoising gain offered by the proposed rank-one approximation based detector.



https://doi.org/10.1109/LWC.2021.3129460
Harounabadi, Mehdi; Soleymani, Dariush M.; Bhadauria, Shubhangi; Leyh, Martin; Roth-Mandutz, Elke
V2X in 3GPP standardization: NR sidelink in Release-16 and beyond. - In: IEEE communications standards magazine, ISSN 2471-2833, Bd. 5 (2021), 1, S. 12-21

The 5G mobile network brings several new features that can be applied to existing and new applications. High reliability, low latency, and high data rate are some of the features that fulfill the requirements of vehicular networks. Vehicular networks aim to provide safety for road users and several additional advantages such as enhanced traffic efficiency and in-vehicle infotainment services. This article summarizes the most important aspects of NR-V2X, which is standardized by 3GPP, focusing on sidelink communication. The main part of this work belongs to 3GPP Release 16, which is the first 3GPP release for NR-V2X, and the work/study items of the future Release 17.



https://doi.org/10.1109/MCOMSTD.001.2000070